Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. [electronic resource]
Producer: 20081117Description: 609-21 p. digitalISSN:- 1474-9726
- Aged
- Aging -- genetics
- Cell Proliferation
- Cells, Cultured
- Cysteine Endopeptidases -- biosynthesis
- Down-Regulation -- genetics
- Endopeptidases -- biosynthesis
- Enzyme Repression -- genetics
- Fibroblasts -- enzymology
- Humans
- RNA Interference -- physiology
- SUMO-1 Protein -- metabolism
- Tumor Suppressor Protein p53 -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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