Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells. [electronic resource]
Producer: 20081030Description: 740-5 p. digitalISSN:- 1532-2335
- Cell Line, Tumor
- Colorectal Neoplasms -- drug therapy
- Fluorouracil -- pharmacology
- Folic Acid Antagonists -- pharmacology
- Gene Expression Regulation, Neoplastic
- Humans
- Inhibitory Concentration 50
- Mutation
- RNA, Messenger -- genetics
- Substrate Specificity
- Thymidylate Synthase -- antagonists & inhibitors
- Transfection
- Tumor Suppressor Protein p53 -- genetics
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Publication Type: Journal Article
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