Effects of the pan-selectin antagonist bimosiamose (TBC1269) in experimental human endotoxemia. [electronic resource]
Producer: 20080922Description: 475-82 p. digitalISSN:- 1073-2322
- Adolescent
- Adult
- Blood Coagulation -- drug effects
- Blood Platelets -- drug effects
- Cell Adhesion Molecules -- antagonists & inhibitors
- Cross-Over Studies
- Double-Blind Method
- Endotoxemia -- chemically induced
- Flow Cytometry
- Hemodynamics -- drug effects
- Hexanes -- pharmacology
- Humans
- Inflammation -- metabolism
- Interleukin-6 -- metabolism
- Leukocytes -- drug effects
- Lipopolysaccharides
- Male
- Mannose -- analogs & derivatives
- Platelet Membrane Glycoprotein IIb -- metabolism
- RNA, Messenger -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Selectins -- metabolism
- Thromboplastin -- genetics
- Time Factors
- Tumor Necrosis Factor-alpha -- metabolism
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Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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