Patupilone-induced apoptosis is mediated by mitochondrial reactive oxygen species through Bim relocalization to mitochondria. [electronic resource]
Producer: 20081027Description: 1072-83 p. digitalISSN:- 1521-0111
- Apoptosis -- drug effects
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cytochromes c -- metabolism
- Dose-Response Relationship, Drug
- Epothilones -- pharmacology
- Humans
- Indicators and Reagents -- metabolism
- Membrane Potential, Mitochondrial -- drug effects
- Mitochondria -- metabolism
- Neuroblastoma -- drug therapy
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- physiology
- Tetrazolium Salts -- metabolism
- Time Factors
- Tubulin Modulators -- pharmacology
- bcl-2-Associated X Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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