The kinase inhibitor LS104 induces apoptosis, enhances cytotoxic effects of chemotherapeutic drugs and is targeting the receptor tyrosine kinase FLT3 in acute myeloid leukemia. [electronic resource]
Producer: 20081003Description: 1698-708 p. digitalISSN:- 0145-2126
- Acrylonitrile -- analogs & derivatives
- Adult
- Aged
- Aged, 80 and over
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- Bone Marrow -- drug effects
- Cell Differentiation -- drug effects
- Cell Proliferation -- drug effects
- Colony-Forming Units Assay
- Cytarabine -- administration & dosage
- Daunorubicin -- administration & dosage
- Drug Therapy, Combination
- Female
- Fluorescent Antibody Technique
- Humans
- Leukemia, Myeloid, Acute -- drug therapy
- Male
- Mice
- Middle Aged
- Point Mutation
- Signal Transduction -- drug effects
- Styrenes -- pharmacology
- Tissue Distribution
- Tumor Cells, Cultured
- fms-Like Tyrosine Kinase 3 -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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