A pore-blocking hydrophobic motif at the cytoplasmic aperture of the closed-state Nav1.7 channel is disrupted by the erythromelalgia-associated F1449V mutation. [electronic resource]
Producer: 20081003Description: 24118-27 p. digitalISSN:- 0021-9258
- Amino Acid Motifs
- Amino Acid Substitution
- Cell Line
- Erythromelalgia -- genetics
- Humans
- Hydrophobic and Hydrophilic Interactions
- Models, Biological
- Mutation, Missense
- NAV1.7 Voltage-Gated Sodium Channel
- Nociceptors -- chemistry
- Protein Structure, Secondary -- genetics
- Protein Structure, Tertiary -- genetics
- Sodium Channels -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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