Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy. [electronic resource]
Producer: 20081110Description: 1031-43 p. digitalISSN:- 1065-6995
- Animals
- Bromodeoxyuridine -- metabolism
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cellular Senescence -- drug effects
- Cisplatin -- pharmacology
- Colonic Neoplasms -- pathology
- DNA Damage
- DNA, Neoplasm -- biosynthesis
- Diploidy
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm -- drug effects
- Gene Duplication -- drug effects
- Mitosis -- drug effects
- Phenotype
- Polyploidy
- Rats
- Time Factors
- Tumor Escape -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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