Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitro. [electronic resource]
Producer: 20080812Description: 3895-904 p. digitalISSN:- 1520-4804
- Animals
- Antineoplastic Agents -- chemical synthesis
- Breast Neoplasms -- metabolism
- Carbamates -- chemistry
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Drug Design
- Enzyme Inhibitors -- chemical synthesis
- Histone Deacetylase Inhibitors
- Histone Deacetylases -- metabolism
- Humans
- Male
- Mice
- Mice, SCID
- Molecular Structure
- Prodrugs -- chemical synthesis
- Prostatic Neoplasms -- metabolism
- Structure-Activity Relationship
- Tretinoin -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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