Mutations close to functional motif IV in HSV-1 UL5 helicase that confer resistance to HSV helicase-primase inhibitors, variously affect virus growth rate and pathogenicity. [electronic resource]
Producer: 20081124Description: 81-5 p. digitalISSN:- 0166-3542
- Animals
- Antiviral Agents -- pharmacology
- Chlorocebus aethiops
- DNA Helicases -- antagonists & inhibitors
- DNA Primase -- antagonists & inhibitors
- Drug Resistance, Viral -- genetics
- Enzyme Inhibitors -- pharmacology
- Herpes Simplex -- pathology
- Herpesvirus 1, Human -- drug effects
- Humans
- Mice
- Mice, Inbred BALB C
- Mutation
- Pyridines -- pharmacology
- Sulfonamides
- Thiazoles -- pharmacology
- Vero Cells
- Viral Proteins -- antagonists & inhibitors
- Virulence
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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