Overcoming S-phase checkpoint-mediated resistance: sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines. [electronic resource]
Producer: 20080918Description: 724-35 p. digitalISSN:- 1521-0111
- Antineoplastic Agents -- pharmacology
- Camptothecin -- analogs & derivatives
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Checkpoint Kinase 1
- DNA, Neoplasm -- biosynthesis
- Deoxycytidine -- analogs & derivatives
- Down-Regulation -- drug effects
- Drug Resistance, Neoplasm -- drug effects
- Drug Screening Assays, Antitumor
- Drug Synergism
- Humans
- Irinotecan
- Phosphorylation -- drug effects
- Protein Kinases -- metabolism
- Protein Processing, Post-Translational -- drug effects
- RNA, Small Interfering -- metabolism
- S Phase -- drug effects
- Tumor Stem Cell Assay
- Gemcitabine
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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