Arsenic interferes with the signaling transduction pathway of T cell receptor activation by increasing basal and induced phosphorylation of Lck and Fyn in spleen cells. [electronic resource]
Producer: 20080722Description: 216-26 p. digitalISSN:- 0041-008X
- Animals
- Apoptosis -- drug effects
- Arsenic -- pharmacology
- Body Weight -- drug effects
- CD28 Antigens -- metabolism
- CD3 Complex -- metabolism
- Cell Proliferation -- drug effects
- Cell Survival
- Cytokines -- biosynthesis
- Drinking -- drug effects
- Eating -- drug effects
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck) -- biosynthesis
- Male
- Mice
- Mice, Inbred C57BL
- Monocytes -- drug effects
- Necrosis
- Phosphorylation
- Proto-Oncogene Proteins c-fyn -- biosynthesis
- Receptors, Antigen, T-Cell -- drug effects
- Signal Transduction -- drug effects
- Spleen -- cytology
- Tetrazolium Salts
- Thiazoles
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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