Native, amyloid fibrils and beta-oligomers of the C-terminal domain of human prion protein display differential activation of complement and bind C1q, factor H and C4b-binding protein directly. [electronic resource]
Producer: 20080729Description: 3213-21 p. digitalISSN:- 0161-5890
- Amyloid -- chemistry
- Complement Activation -- drug effects
- Complement C1q -- chemistry
- Complement C4b-Binding Protein -- immunology
- Complement Factor H -- immunology
- Complement Pathway, Alternative -- drug effects
- Copper -- pharmacology
- Humans
- Mutant Proteins -- chemistry
- PrPC Proteins -- chemistry
- Protein Binding -- drug effects
- Protein Isoforms -- chemistry
- Protein Structure, Quaternary
- Protein Structure, Tertiary
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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