Silencing Bcl-2 in models of mantle cell lymphoma is associated with decreases in cyclin D1, nuclear factor-kappaB, p53, bax, and p27 levels. [electronic resource]
Producer: 20080718Description: 749-58 p. digitalISSN:- 1535-7163
- Animals
- Apoptosis -- physiology
- Blotting, Western
- Cell Proliferation
- Cyclin D
- Cyclin-Dependent Kinase Inhibitor p27 -- genetics
- Cyclins -- genetics
- DNA-Binding Proteins -- genetics
- Disease Models, Animal
- Gene Silencing
- Humans
- Immunoenzyme Techniques
- Immunoprecipitation
- Lymphoma, Mantle-Cell -- genetics
- Male
- Mice
- Mice, Knockout
- Mice, Transgenic
- NF-kappa B -- genetics
- Neoplasm Proteins -- genetics
- Oligonucleotides, Antisense -- pharmacology
- Phosphorylation
- Proto-Oncogene Proteins c-bcl-2 -- antagonists & inhibitors
- Proto-Oncogene Proteins c-mdm2 -- metabolism
- RNA, Messenger -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Thionucleotides -- pharmacology
- Tumor Suppressor Protein p53 -- genetics
- Xenograft Model Antitumor Assays
- bcl-2-Associated X Protein -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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