X-ray structure of 4,4'-dihydroxybenzophenone mimicking sterol substrate in the active site of sterol 14alpha-demethylase (CYP51). [electronic resource]
Producer: 20080717Description: 15152-9 p. digitalISSN:- 0021-9258
- Animals
- Bacterial Proteins -- antagonists & inhibitors
- Benzophenones -- chemistry
- Binding Sites -- drug effects
- Cell Membrane -- metabolism
- Cells, Cultured
- Crystallography, X-Ray
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- chemistry
- Humans
- Macrophages -- metabolism
- Mice
- Models, Molecular
- Mycobacterium tuberculosis -- enzymology
- Mycoses -- drug therapy
- Protein Structure, Tertiary
- Sterols -- biosynthesis
- Structural Homology, Protein
- Tuberculosis -- drug therapy
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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