Treatment with DF 2162, a non-competitive allosteric inhibitor of CXCR1/2, diminishes neutrophil influx and inflammatory hypernociception in mice. [electronic resource]
Producer: 20080619Description: 460-70 p. digitalISSN:- 0007-1188
- Analgesics -- pharmacology
- Animals
- Arthritis, Experimental -- complications
- Benzeneacetamides -- pharmacology
- Cells, Cultured
- Chemokine CXCL1 -- metabolism
- Chemotaxis, Leukocyte -- drug effects
- Cyclooxygenase Inhibitors -- pharmacology
- Dose-Response Relationship, Drug
- Humans
- Hyperalgesia -- etiology
- Indomethacin -- pharmacology
- Inflammation -- complications
- Interleukin-8 -- metabolism
- Male
- Mesylates -- pharmacology
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Knockout
- Neutrophil Infiltration -- drug effects
- Neutrophils -- drug effects
- Pain Measurement
- Receptors, Interleukin-8A -- antagonists & inhibitors
- Receptors, Interleukin-8B -- antagonists & inhibitors
- Receptors, Tumor Necrosis Factor, Type I -- genetics
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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