Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. [electronic resource]
Producer: 20080617Description: 289-310 p. digitalISSN:- 1533-1601
- Adolescent
- Adult
- Air Pollutants -- adverse effects
- Amyloid beta-Peptides -- metabolism
- Blood-Brain Barrier -- drug effects
- Brain -- drug effects
- Child
- Child, Preschool
- Cyclooxygenase 2 -- genetics
- Encephalitis -- chemically induced
- Female
- Humans
- Interleukin-1beta -- genetics
- Lipopolysaccharide Receptors -- genetics
- Male
- Neurons -- drug effects
- Olfactory Bulb -- drug effects
- Particulate Matter -- adverse effects
- Peptide Fragments -- metabolism
- RNA, Messenger -- metabolism
- Up-Regulation -- drug effects
- Urban Health
- Vagus Nerve -- drug effects
- alpha-Synuclein -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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