PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis. [electronic resource]
Producer: 20080422Description: 4745-50 p. digitalISSN:- 1091-6490
- Animals
- Apoptosis -- drug effects
- Cell Hypoxia -- drug effects
- Cell Line
- Enzyme Activation -- drug effects
- Female
- Gene Expression Regulation -- drug effects
- Humans
- Hydroxylation -- drug effects
- Hypoxia-Inducible Factor 1, alpha Subunit -- genetics
- Mice
- Mice, Inbred C57BL
- Necrosis
- Oxygen -- pharmacology
- Procollagen-Proline Dioxygenase -- metabolism
- Proteasome Endopeptidase Complex -- metabolism
- Protein Processing, Post-Translational -- drug effects
- Protein Structure, Tertiary
- Von Hippel-Lindau Tumor Suppressor Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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