An algal sulfated galactan has an unusual dual effect on venous thrombosis due to activation of factor XII and inhibition of the coagulation proteases. [electronic resource]
Producer: 20080515Description: 531-8 p. digitalISSN:- 0340-6245
- Animals
- Anticoagulants -- adverse effects
- Antithrombins -- metabolism
- Bleeding Time
- Blood Coagulation -- drug effects
- Blood Coagulation Tests
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Factor XIIa -- metabolism
- Factor Xa -- metabolism
- Factor Xa Inhibitors
- Female
- Fibrinolytic Agents -- adverse effects
- Galactans -- adverse effects
- Hemorrhage -- chemically induced
- Heparin -- pharmacology
- Heparin Cofactor II -- metabolism
- Humans
- Male
- Molecular Weight
- Protease Inhibitors -- pharmacology
- Rats
- Rats, Wistar
- Rhodophyta -- chemistry
- Sulfates -- adverse effects
- Thrombin -- antagonists & inhibitors
- Thrombosis -- blood
- Venous Thrombosis -- blood
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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