N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists. [electronic resource]
Producer: 20080515Description: 3537-49 p. digitalISSN:- 1464-3391
- Aryl Hydrocarbon Hydroxylases -- genetics
- Benzimidazoles -- chemical synthesis
- Cell Line
- Cytochrome P-450 CYP2B6
- Cytochrome P-450 CYP3A -- genetics
- Gene Expression Regulation -- drug effects
- Humans
- Models, Molecular
- Molecular Structure
- Oxidoreductases, N-Demethylating -- genetics
- Pregnane X Receptor
- RNA, Messenger -- genetics
- Receptors, Steroid -- agonists
- Structure-Activity Relationship
- Sulfonamides -- chemical synthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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