A general and islet cell-enriched overexpression of IGF-I results in normal islet cell growth, hypoglycemia, and significant resistance to experimental diabetes. [electronic resource]
Producer: 20080619Description: E928-38 p. digitalISSN:- 0193-1849
- Animals
- Blotting, Northern
- Cell Proliferation
- Diabetes Mellitus, Experimental -- genetics
- Fluorescent Antibody Technique
- Gluconeogenesis -- genetics
- Glucose Tolerance Test
- Humans
- Hypoglycemia -- metabolism
- Immunohistochemistry
- Insulin -- blood
- Insulin Resistance -- physiology
- Insulin-Like Growth Factor I -- biosynthesis
- Islets of Langerhans -- metabolism
- Metallothionein -- biosynthesis
- Mice
- Mice, Transgenic
- Pyruvates -- metabolism
- RNA -- biosynthesis
- Rats
- Reverse Transcriptase Polymerase Chain Reaction
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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