The synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. [electronic resource]
Producer: 20080320Description: 118-27 p. digitalISSN:- 1532-4192
- Adipocytes -- cytology
- Apoptosis -- drug effects
- Blotting, Western
- Cell Proliferation -- drug effects
- Cerulenin -- pharmacology
- Drug Synergism
- Drug Therapy, Combination
- Fatty Acid Synthases -- antagonists & inhibitors
- Fatty Acid Synthesis Inhibitors -- pharmacology
- Glycerolphosphate Dehydrogenase -- metabolism
- Humans
- Imidazoles -- pharmacology
- Liposarcoma -- drug therapy
- Oleanolic Acid -- analogs & derivatives
- Palmitic Acid -- metabolism
- Tumor Cells, Cultured -- drug effects
- fas Receptor -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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