A novel collagen-binding peptide promotes osteogenic differentiation via Ca2+/calmodulin-dependent protein kinase II/ERK/AP-1 signaling pathway in human bone marrow-derived mesenchymal stem cells. [electronic resource]
Producer: 20080508Description: 613-24 p. digitalISSN:- 0898-6568
- Animals
- Bone Marrow Cells -- drug effects
- Calcification, Physiologic -- drug effects
- Calcium Channels -- drug effects
- Calcium Signaling -- drug effects
- Calcium-Calmodulin-Dependent Protein Kinase Type 2 -- antagonists & inhibitors
- Cell Differentiation -- drug effects
- Cell Line
- Cell Movement -- drug effects
- Cell Proliferation -- drug effects
- Cells, Cultured
- Collagen -- metabolism
- Cyclic AMP Response Element-Binding Protein -- metabolism
- Dose-Response Relationship, Drug
- Enzyme Activation
- Extracellular Signal-Regulated MAP Kinases -- antagonists & inhibitors
- Humans
- Mesenchymal Stem Cells -- drug effects
- Osteoblasts -- drug effects
- Osteogenesis -- drug effects
- Osteopontin -- metabolism
- Peptide Fragments -- metabolism
- Phosphorylation
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-jun -- metabolism
- Signal Transduction -- drug effects
- Time Factors
- Transcription Factor AP-1 -- genetics
- Transcriptional Activation -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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