Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy. [electronic resource]
Producer: 20080505Description: 449-69 p. digitalISSN:- 0022-2623
- Aminoquinolines -- chemical synthesis
- Animals
- Biological Availability
- Blood-Brain Barrier -- metabolism
- Cell Line
- Cells, Cultured
- Cyclic AMP Response Element-Binding Protein -- genetics
- Fibroblasts -- drug effects
- Folic Acid Antagonists -- chemical synthesis
- Heterozygote
- Humans
- Mice
- Models, Molecular
- Molecular Conformation
- Muscular Atrophy, Spinal -- drug therapy
- Nerve Tissue Proteins -- genetics
- Permeability
- Piperidines -- chemical synthesis
- Promoter Regions, Genetic
- Quinazolines -- chemical synthesis
- RNA-Binding Proteins -- genetics
- SMN Complex Proteins
- Spinal Muscular Atrophies of Childhood -- genetics
- Stereoisomerism
- Structure-Activity Relationship
- Survival of Motor Neuron 1 Protein
- Survival of Motor Neuron 2 Protein
- Tetrahydrofolate Dehydrogenase -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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