SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. [electronic resource]
Producer: 20080421Description: 665-71 p. digitalISSN:- 1524-4636
- Activin Receptors, Type I -- antagonists & inhibitors
- Adenosine Triphosphate -- metabolism
- Administration, Oral
- Animals
- Azabicyclo Compounds -- administration & dosage
- Binding Sites
- Carotid Artery Injuries -- drug therapy
- Cell Line
- Fibroblasts -- drug effects
- Fibrosis
- Humans
- Male
- Myoblasts, Smooth Muscle -- drug effects
- Protein Kinase Inhibitors -- administration & dosage
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Rats
- Rats, Sprague-Dawley
- Receptor, Transforming Growth Factor-beta Type I
- Receptors, Transforming Growth Factor beta -- antagonists & inhibitors
- Transforming Growth Factor beta -- physiology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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