Celecoxib inhibits production of MMP and NO via down-regulation of NF-kappaB and JNK in a PGE2 independent manner in human articular chondrocytes. [electronic resource]
Producer: 20081028Description: 727-36 p. digitalISSN:- 0172-8172
- Aged
- Cartilage, Articular -- cytology
- Celecoxib
- Cells, Cultured
- Chondrocytes -- drug effects
- Cyclooxygenase 2 -- metabolism
- Cyclooxygenase Inhibitors -- pharmacology
- Dinoprostone -- pharmacology
- Down-Regulation -- drug effects
- Enzyme Activation -- drug effects
- Humans
- Interleukin-1beta -- pharmacology
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Matrix Metalloproteinase 1 -- biosynthesis
- Matrix Metalloproteinase 3 -- biosynthesis
- Matrix Metalloproteinases -- biosynthesis
- NF-kappa B -- metabolism
- Nitric Oxide -- biosynthesis
- Nitric Oxide Synthase Type II -- metabolism
- Phosphorylation -- drug effects
- Pyrazoles -- pharmacology
- Sulfonamides -- pharmacology
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Publication Type: Journal Article
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