Substrate-bound insulin-like growth factor (IGF)-I-IGF binding protein-vitronectin-stimulated breast cell migration is enhanced by coactivation of the phosphatidylinositide 3-Kinase/AKT pathway by alphav-integrins and the IGF-I receptor. [electronic resource]
Producer: 20080422Description: 1075-90 p. digitalISSN:- 0013-7227
- Breast -- metabolism
- Breast Neoplasms -- metabolism
- Cell Line
- Cell Line, Tumor
- Cell Movement -- physiology
- Drug Synergism
- Female
- Humans
- Insulin-Like Growth Factor Binding Proteins -- physiology
- Insulin-Like Growth Factor I -- physiology
- Integrin alphaV -- metabolism
- Mitogen-Activated Protein Kinase Kinases -- metabolism
- Phosphatidylinositol 3-Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Receptor, IGF Type 1 -- metabolism
- Vitronectin -- physiology
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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