Proteasomal inhibition stabilizes topoisomerase IIalpha protein and reverses resistance to the topoisomerase II poison ethonafide (AMP-53, 6-ethoxyazonafide). [electronic resource]
Producer: 20080418Description: 883-90 p. digitalISSN:- 1873-2968
- Antigens, Neoplasm
- Antineoplastic Agents -- pharmacology
- Boronic Acids -- pharmacology
- Bortezomib
- Cell Line, Tumor
- Cell Survival -- drug effects
- DNA Topoisomerases, Type II
- DNA-Binding Proteins -- antagonists & inhibitors
- Drug Resistance, Neoplasm -- drug effects
- Drug Synergism
- Humans
- Isoquinolines -- pharmacology
- Multiple Myeloma -- enzymology
- Protease Inhibitors -- pharmacology
- Pyrazines -- pharmacology
- Topoisomerase II Inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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