Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein. [electronic resource]
Producer: 20080318Description: 328-37 p. digitalISSN:- 0041-008X
- Acrolein -- chemistry
- Administration, Oral
- Animals
- Anticarcinogenic Agents -- chemistry
- Coffee -- chemistry
- Diet
- Diterpenes -- chemistry
- Dose-Response Relationship, Drug
- Enzyme Induction -- drug effects
- Gene Expression Regulation, Enzymologic -- drug effects
- Gene Silencing
- Glutathione Transferase -- genetics
- Intestine, Small -- drug effects
- Isoenzymes -- genetics
- Liver -- drug effects
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- NAD(P)H Dehydrogenase (Quinone)
- NADPH Dehydrogenase -- genetics
- NF-E2-Related Factor 2 -- genetics
- RNA, Messenger -- metabolism
- Response Elements -- drug effects
- Transcriptional Activation
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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