Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation. [electronic resource]
Producer: 20080215Description: 3049-58 p. digitalISSN:- 1535-7163
- Adenosine Triphosphate -- metabolism
- Aerobiosis -- drug effects
- Anaerobiosis -- drug effects
- Cell Death -- drug effects
- Cell Line, Tumor
- Cell Survival -- drug effects
- Deoxyglucose -- pharmacology
- Fluorodeoxyglucose F18 -- pharmacology
- Glycolysis -- drug effects
- Glycosylation -- drug effects
- Humans
- Mannose -- pharmacology
- Models, Biological
- Neoplasms -- pathology
- Oligosaccharides -- metabolism
- Oxygen -- metabolism
- Oxygen Consumption -- drug effects
- Protein Folding
- Transcription Factor CHOP -- genetics
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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