Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients. [electronic resource]
Producer: 20080122Description: 1057-64 p. digitalISSN:- 1744-6872
- Acute Coronary Syndrome -- blood
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Aryl Hydrocarbon Hydroxylases -- genetics
- Aspirin -- therapeutic use
- Clopidogrel
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- genetics
- Female
- Humans
- Male
- Middle Aged
- Mixed Function Oxygenases -- genetics
- Pharmacogenetics
- Platelet Aggregation -- drug effects
- Platelet Aggregation Inhibitors -- metabolism
- Polymorphism, Genetic
- Receptors, Purinergic P2 -- genetics
- Receptors, Purinergic P2Y12
- Ticlopidine -- analogs & derivatives
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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