Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation. [electronic resource]
Producer: 20080214Description: 1428-1436 p. digitalISSN:- 0021-9258
- Adaptor Proteins, Signal Transducing -- metabolism
- Animals
- COS Cells
- Carcinoma, Hepatocellular -- enzymology
- Cell Proliferation -- drug effects
- Chlorocebus aethiops
- Clone Cells
- Cyclin-Dependent Kinase Inhibitor p16 -- metabolism
- Enzyme Activation -- drug effects
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- GRB2 Adaptor Protein -- metabolism
- Hepatocyte Growth Factor -- pharmacology
- Humans
- Liver Neoplasms -- enzymology
- MAP Kinase Signaling System -- drug effects
- Mutant Proteins -- metabolism
- Phosphorylation -- drug effects
- Protein Binding -- drug effects
- Proto-Oncogene Proteins c-met -- metabolism
- Rats
- Recombinant Proteins -- metabolism
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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