Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines. [electronic resource]
Producer: 20080215Description: 3028-38 p. digitalISSN:- 1535-7163
- Adenosine Triphosphate -- pharmacology
- Allosteric Regulation -- drug effects
- Animals
- Catalysis -- drug effects
- Cell Line, Tumor
- Cysteine -- metabolism
- Down-Regulation -- drug effects
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- chemistry
- Humans
- Kinetics
- Naphthoquinones -- chemistry
- Phosphorylation -- drug effects
- Protein Biosynthesis -- drug effects
- Protein Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- RNA Caps -- metabolism
- Rats
- Structure-Activity Relationship
- Substrate Specificity -- drug effects
- TOR Serine-Threonine Kinases
- Time Factors
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Publication Type: Journal Article
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