New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90. [electronic resource]
Producer: 20080227Description: 6189-200 p. digitalISSN:- 0022-2623
- Antineoplastic Agents -- chemical synthesis
- Apoptosis
- Breast Neoplasms
- Caspases -- metabolism
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cyclin-Dependent Kinase 4 -- metabolism
- Drug Screening Assays, Antitumor
- Estradiol -- pharmacology
- Estrogen Receptor alpha -- metabolism
- Female
- Flow Cytometry
- HSP90 Heat-Shock Proteins -- antagonists & inhibitors
- Humans
- Novobiocin -- analogs & derivatives
- Proteasome Endopeptidase Complex -- metabolism
- Proto-Oncogene Proteins c-raf -- metabolism
- Receptor, ErbB-2 -- metabolism
- Signal Transduction
- Structure-Activity Relationship
- Transcription, Genetic -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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