Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver. [electronic resource]
Producer: 20080514Description: 1239-48 p. digitalISSN:- 0278-6915
- Aflatoxin B1 -- toxicity
- Animals
- Anticarcinogenic Agents -- pharmacology
- Antioxidants -- metabolism
- Blotting, Western
- Carcinogens -- toxicity
- Coffee -- chemistry
- Cytochrome P-450 CYP1A1 -- metabolism
- Cytochrome P-450 CYP1A2 -- metabolism
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- metabolism
- Dose-Response Relationship, Drug
- Genes, Reporter
- Glutathione -- metabolism
- Glutathione Transferase -- metabolism
- Hepatocytes -- drug effects
- Humans
- Liver Neoplasms, Experimental -- chemically induced
- Luciferases -- metabolism
- Male
- NF-E2-Related Factor 2 -- biosynthesis
- Rats
- Rats, Sprague-Dawley
- Regulatory Elements, Transcriptional
- Reverse Transcriptase Polymerase Chain Reaction
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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