Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration. [electronic resource]
Producer: 20080314Description: 2458-68 p. digitalISSN:- 0953-816X
- Alzheimer Disease -- drug therapy
- Amyloid beta-Peptides -- antagonists & inhibitors
- Animals
- Animals, Newborn
- Antibodies -- immunology
- Brain -- drug effects
- Cells, Cultured
- Coculture Techniques
- Cytokines -- drug effects
- Down-Regulation -- drug effects
- Encephalitis -- chemically induced
- Gliosis -- chemically induced
- Glycosylation
- Humans
- Injections, Intravenous
- Mice
- Mice, Transgenic
- Microglia -- drug effects
- Phagocytosis -- drug effects
- Polysaccharides -- chemistry
- Rats
- Rats, Wistar
- Treatment Outcome
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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