PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation. [electronic resource]
Producer: 20080410Description: L24-33 p. digitalISSN:- 1040-0605
- Animals
- Bleomycin -- adverse effects
- Cyclic Nucleotide Phosphodiesterases, Type 5
- Enzyme Activation
- Hypertension, Pulmonary -- pathology
- Male
- Mice
- Mice, Inbred C57BL
- Phosphodiesterase 5 Inhibitors
- Phosphodiesterase Inhibitors -- therapeutic use
- Piperazines -- therapeutic use
- Pulmonary Fibrosis -- chemically induced
- Purines -- therapeutic use
- Reactive Oxygen Species -- metabolism
- Sildenafil Citrate
- Sulfones -- therapeutic use
- Ventricular Dysfunction, Right -- chemically induced
- rho-Associated Kinases -- metabolism
- rhoA GTP-Binding Protein -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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