A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation. [electronic resource]
Producer: 20080326Description: 103-8 p. digitalISSN:- 0304-3940
- Aged
- Aged, 80 and over
- Alternative Splicing -- genetics
- Alzheimer Disease -- enzymology
- Amyloid Precursor Protein Secretases -- chemistry
- Amyloid beta-Peptides -- biosynthesis
- Amyloid beta-Protein Precursor -- metabolism
- Aspartic Acid Endopeptidases -- chemistry
- Binding Sites -- genetics
- Brain -- enzymology
- Cell Line
- Cell Line, Tumor
- Codon, Nonsense -- genetics
- Conserved Sequence -- genetics
- Enzyme Activation -- genetics
- Female
- Humans
- Isoenzymes -- chemistry
- Male
- Middle Aged
- Proteasome Endopeptidase Complex -- genetics
- Protein Structure, Tertiary -- genetics
- RNA Stability -- genetics
- RNA, Messenger -- genetics
- Stress, Physiological -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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