Combination of all-trans retinoic acid and interferon-gamma upregulated p27(kip1) and down regulated CDK2 to cause cell cycle arrest leading to differentiation and apoptosis in human glioblastoma LN18 (PTEN-proficient) and U87MG (PTEN-deficient) cells. [electronic resource]
Producer: 20080904Description: 407-16 p. digitalISSN:- 0344-5704
- Antineoplastic Combined Chemotherapy Protocols -- administration & dosage
- Apoptosis -- drug effects
- Astrocytes -- drug effects
- Blotting, Western
- Cell Culture Techniques
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cyclin-Dependent Kinase 2 -- antagonists & inhibitors
- Cyclin-Dependent Kinase Inhibitor p27 -- biosynthesis
- Cytochromes c -- metabolism
- Cytosol -- drug effects
- DNA Fragmentation -- drug effects
- Down-Regulation
- Glioblastoma -- enzymology
- Humans
- In Situ Nick-End Labeling
- Interferon-gamma -- administration & dosage
- Mitochondria -- drug effects
- PTEN Phosphohydrolase -- biosynthesis
- Recombinant Proteins
- Tretinoin -- administration & dosage
- Up-Regulation
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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