Celastrol inhibits polyglutamine aggregation and toxicity though induction of the heat shock response. [electronic resource]
Producer: 20080313Description: 1421-8 p. digitalISSN:- 0946-2716
- Animals
- Cell Survival -- drug effects
- DNA-Binding Proteins -- deficiency
- Dose-Response Relationship, Drug
- Fibroblasts -- drug effects
- Gene Expression -- drug effects
- HSP70 Heat-Shock Proteins -- metabolism
- HeLa Cells
- Heat Shock Transcription Factors
- Humans
- Mice
- Mice, Knockout
- Neurons -- drug effects
- PC12 Cells
- Pentacyclic Triterpenes
- Peptides -- chemistry
- Protein Conformation
- Rats
- Recombinant Fusion Proteins -- metabolism
- Solubility
- Time Factors
- Transcription Factors -- deficiency
- Transfection
- Triterpenes -- pharmacology
- Up-Regulation
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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