Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells. [electronic resource]
Producer: 20071221Description: 503-14 p. digitalISSN:- 0867-5910
- Cell Survival -- drug effects
- Cells, Cultured
- Dose-Response Relationship, Drug
- Down-Regulation -- drug effects
- Endothelium, Vascular -- cytology
- Fluorobenzenes -- pharmacology
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Immunoblotting
- Mevalonic Acid -- pharmacology
- Nitric Oxide -- metabolism
- Nitric Oxide Synthase Type II -- genetics
- Nitric Oxide Synthase Type III -- genetics
- Polyisoprenyl Phosphates -- pharmacology
- Pyridines -- pharmacology
- Pyrimidines -- pharmacology
- RNA, Messenger -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Rosuvastatin Calcium
- Sesquiterpenes -- pharmacology
- Sulfonamides -- pharmacology
- Terpenes -- metabolism
- Time Factors
- Tumor Necrosis Factor-alpha -- genetics
- Umbilical Veins -- cytology
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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