The activity of zoledronic Acid on neuroblastoma bone metastasis involves inhibition of osteoclasts and tumor cell survival and proliferation. [electronic resource]
Producer: 20071031Description: 9346-55 p. digitalISSN:- 0008-5472
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Bone Density Conservation Agents -- pharmacology
- Bone Neoplasms -- metabolism
- Caspase 3 -- metabolism
- Cell Growth Processes -- drug effects
- Cell Survival -- drug effects
- Cyclophosphamide -- administration & dosage
- Diphosphonates -- administration & dosage
- Enzyme Activation -- drug effects
- Humans
- Imidazoles -- administration & dosage
- Mice
- Mice, Inbred BALB C
- Mitogen-Activated Protein Kinase 1 -- antagonists & inhibitors
- Mitogen-Activated Protein Kinase 3 -- antagonists & inhibitors
- Neuroblastoma -- drug therapy
- Osteoclasts -- drug effects
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Proto-Oncogene Proteins c-bcl-2 -- antagonists & inhibitors
- Topotecan -- administration & dosage
- Xenograft Model Antitumor Assays
- Zoledronic Acid
- ras Proteins -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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