Cerebral clearance of human amyloid-beta peptide (1-40) across the blood-brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes. [electronic resource]
Producer: 20080108Description: 2482-90 p. digitalISSN:- 1471-4159
- Alzheimer Disease -- metabolism
- Amyloid beta-Peptides -- metabolism
- Animals
- Apolipoproteins E -- metabolism
- Blood-Brain Barrier -- drug effects
- Cell Line
- Cerebral Cortex -- drug effects
- Dimerization
- Endocytosis -- physiology
- Humans
- Lactoferrin -- metabolism
- Ligands
- Low Density Lipoprotein Receptor-Related Protein-1 -- drug effects
- Macromolecular Substances -- metabolism
- Male
- Metabolic Clearance Rate -- physiology
- Mice
- Peptide Fragments -- metabolism
- Protein Binding -- physiology
- Rats
- Rats, Sprague-Dawley
- alpha-Macroglobulins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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