In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure. [electronic resource]
Producer: 20080228Description: H88-98 p. digitalISSN:- 0363-6135
- Adipokines
- Animals
- Apelin
- Apelin Receptors
- Basic Helix-Loop-Helix Transcription Factors -- genetics
- Carrier Proteins -- genetics
- Cell Hypoxia
- Cells, Cultured
- Coronary Vessels -- surgery
- Disease Models, Animal
- Endothelial Cells -- metabolism
- Female
- Gene Expression Profiling
- Genes, Reporter
- Heart Failure -- etiology
- Humans
- Hypoxia -- genetics
- Hypoxia-Inducible Factor 1, alpha Subunit -- genetics
- Intercellular Signaling Peptides and Proteins -- metabolism
- Lac Operon
- Ligation
- Lung -- metabolism
- Mice
- Mice, Transgenic
- Myocardial Ischemia -- complications
- Myocardium -- metabolism
- Promoter Regions, Genetic
- Quadriceps Muscle -- metabolism
- RNA, Messenger -- metabolism
- Receptors, G-Protein-Coupled -- metabolism
- Signal Transduction -- genetics
- Time Factors
- Transfection
- Up-Regulation
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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