Differential effects on angiogenesis of two antimalarial compounds, dihydroartemisinin and artemisone: implications for embryotoxicity. [electronic resource]
Producer: 20071227Description: 66-74 p. digitalISSN:- 0300-483X
- Adult
- Animals
- Antimalarials -- toxicity
- Aorta, Thoracic -- drug effects
- Artemisinins -- toxicity
- Capillaries -- drug effects
- Cell Line
- Cell Proliferation -- drug effects
- Cytokines -- biosynthesis
- Dose-Response Relationship, Drug
- Embryo, Mammalian -- pathology
- Endothelium, Vascular -- drug effects
- Enzyme-Linked Immunosorbent Assay
- Female
- Fibronectins -- biosynthesis
- Humans
- Male
- Neovascularization, Physiologic -- drug effects
- Neural Tube -- drug effects
- Pregnancy
- Rats
- Rats, Inbred F344
- Sesquiterpenes -- toxicity
- Teratogens
- Tetrazolium Salts
- Thiazoles
- Vascular Endothelial Growth Factor A -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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