Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane. [electronic resource]
Producer: 20071127Description: 8839-46 p. digitalISSN:- 0008-5472
- Animals
- Antibiotics, Antineoplastic -- antagonists & inhibitors
- DNA Breaks, Double-Stranded
- DNA Topoisomerases, Type II -- chemistry
- DNA-Binding Proteins -- antagonists & inhibitors
- Doxorubicin -- antagonists & inhibitors
- Drug Interactions
- Heart Diseases -- chemically induced
- Histones -- metabolism
- Humans
- Mice
- Models, Molecular
- Myocytes, Cardiac -- drug effects
- Proteasome Endopeptidase Complex -- metabolism
- Proteasome Inhibitors
- Protein Conformation
- Razoxane -- pharmacology
- Topoisomerase II Inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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