Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation. [electronic resource]
Producer: 20071212Description: 30707-17 p. digitalISSN:- 0021-9258
- Animals
- Anti-Inflammatory Agents -- toxicity
- Cell Death -- drug effects
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cytoprotection -- drug effects
- Dexamethasone -- toxicity
- Diabetes Mellitus, Experimental -- genetics
- Genes, Dominant
- Insulin -- genetics
- Insulin-Secreting Cells -- metabolism
- Janus Kinase 2 -- antagonists & inhibitors
- Mice
- Mice, Transgenic
- Mutation
- Placental Lactogen -- genetics
- Prolactin -- genetics
- Promoter Regions, Genetic -- genetics
- RNA, Small Interfering -- metabolism
- Rats
- STAT5 Transcription Factor -- genetics
- Signal Transduction
- Up-Regulation -- drug effects
- bcl-X Protein -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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