The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity. [electronic resource]
Producer: 20071015Description: 2290-302 p. digitalISSN:- 1535-7163
- Animals
- Antineoplastic Agents -- pharmacology
- Camptothecin -- analogs & derivatives
- Carbazoles -- pharmacology
- Cell Death -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Comet Assay
- DNA Damage
- DNA Repair -- drug effects
- Dacarbazine -- analogs & derivatives
- Drug Resistance, Neoplasm -- drug effects
- Drug Synergism
- Enzyme Inhibitors -- pharmacology
- G2 Phase -- drug effects
- Humans
- Irinotecan
- Mice
- Phthalimides -- pharmacology
- Poly Adenosine Diphosphate Ribose -- metabolism
- Poly(ADP-ribose) Polymerase Inhibitors
- Rats
- Temozolomide
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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