Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer. [electronic resource]
Producer: 20080304Description: 2451-8 p. digitalISSN:- 1460-2180
- Adenocarcinoma, Follicular -- drug therapy
- Animals
- Apoptosis
- Caspase 3 -- metabolism
- Cell Movement -- drug effects
- Cell Proliferation -- drug effects
- Chromones -- pharmacology
- Cyclin D1 -- metabolism
- Cyclin-Dependent Kinase Inhibitor p27 -- metabolism
- Lung Neoplasms -- drug therapy
- Matrix Metalloproteinase 2 -- metabolism
- Mice
- Mice, Mutant Strains
- Morpholines -- pharmacology
- Neoplasm Invasiveness
- Phosphoinositide-3 Kinase Inhibitors
- Protein Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Signal Transduction
- TOR Serine-Threonine Kinases
- Thyroid Hormone Receptors beta -- genetics
- Thyroid Neoplasms -- drug therapy
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, N.I.H., Intramural
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