Disulfide Bond-mediated multimerization of Ask1 and its reduction by thioredoxin-1 regulate H(2)O(2)-induced c-Jun NH(2)-terminal kinase activation and apoptosis. [electronic resource]
Producer: 20071127Description: 3903-13 p. digitalISSN:- 1059-1524
- Apoptosis -- drug effects
- Cysteine -- genetics
- Disulfides -- metabolism
- Enzyme Activation -- drug effects
- HeLa Cells
- Humans
- Hydrogen Peroxide -- pharmacology
- JNK Mitogen-Activated Protein Kinases -- metabolism
- MAP Kinase Kinase Kinase 5 -- chemistry
- Models, Biological
- Mutation -- genetics
- Oxidation-Reduction -- drug effects
- Phosphorylation -- drug effects
- Protein Structure, Quaternary
- Signal Transduction -- drug effects
- Thioredoxins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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