Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome. [electronic resource]
Producer: 20080314Description: 631-41 p. digitalISSN:- 1460-2083
- Abnormalities, Multiple -- genetics
- Animals
- Animals, Newborn
- Ankle -- abnormalities
- Codon, Nonsense
- Contractile Proteins -- chemistry
- Crosses, Genetic
- Dimerization
- Disease Models, Animal
- Embryo, Mammalian
- Filamins
- Gene Expression Regulation, Developmental
- Genes, Recessive
- Heterozygote
- Homozygote
- Humans
- Metacarpus -- abnormalities
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Microfilament Proteins -- chemistry
- Models, Biological
- Models, Genetic
- Molecular Weight
- Mutation
- Osteochondrodysplasias -- genetics
- Phenotype
- Protein Structure, Tertiary
- Spine -- abnormalities
- Syndrome
- Synostosis -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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